Post-transplant lymphoproliferative disorder (PTLD) is a leading cause of cancer death in solid organ transplant recipients (SOTRs). Relapsed or refractory (R/R) PTLD portends a high risk of death and effective management is not well established. CD19-targeted CAR-T cell therapy has been utilized, but the risks and benefits are unknown. We report the first case of diffuse large B-cell lymphoma (DLBCL) PTLD treated with lisocabtagene maraleucel and present a systematic literature review of SOTRs with PTLD treated with CD19 CAR-T therapy.
Transforming the lives of people with cancer and organ transplants through integrated healthcare and research.
The Center for Innovations in Cancer & Transplant was founded with the following goals:
- To provide outstanding multidisciplinary clinical care for pre- and post-transplant patients with cancer.
- To lead exceptional, multidimensional, patient-focused research of cancer before and after organ transplant through a robust bioregistry and collaborative research network.
We seek to do this through a first-of-its kind clinic, a new bioregistry, and our own original research.
Learn more about the Center
The first-of-its-kind multidisciplinary consult clinic for organ transplant candidates and recipients with cancer.
Investigating the immune mechanisms and epidemiology of cancer with solid organ transplantation.
CD19 CAR-T therapy in solid organ transplant recipients: case report and systematic review
Immune checkpoint inhibitor use in solid organ transplant recipients: a systematic review
Chronic immunosuppression in solid organ transplant recipients (SOTRs) leads to an increased risk of a wide variety of cancers. Immune checkpoint inhibitor (ICI) therapy is indicated for many of these; however, the risks and benefits of ICI use in the SOTR population have not been well characterized. We performed a systematic literature review identifying 119 reported cases of ICI use among SOTRs. Treatments used included PD-1 inhibition (75.6%), CTLA-4 inhibition (12.6%), PD-L1 inhibition (1.7%), and combination and/or sequential ICI therapy (10.1%). The most common cancers included cutaneous melanoma (35.3%), hepatocellular carcinoma (22.7%), and cutaneous squamous cell carcinoma (18.5%).
Kidney recipients with allograft failure, transition of kidney care (KRAFT): a survey of contemporary practices of transplant providers
Kidney allograft failure and return to dialysis carry a high risk of morbidity. A practice survey was developed by the AST Kidney Pancreas Community of Practice workgroup and distributed electronically to the AST members. There were 104 respondents who represented 92 kidney transplant centers. Most survey respondents were transplant nephrologists at academic centers. The most common approach to immunosuppression management was to withdraw the antimetabolite first (73%), while only 12% responded they would withdraw calcineurin inhibitor (CNI) first.